What? The novel coronavirus 2019 (COVID-19) has threatened the health, economic and social development gained in Africa over the years. Africa has remained to depend for its medical equipment, diagnostic reagents and tools, protective gear and medicines. There has been shortage of medical supplies for COVID-19 due to the limited supply globally. This situation has challenged Africa to think inward. Moreover, WHO has warned African countries to boost their healthcare capabilities to hinder dissemination of the infections. Therefore, the continent must stimulate its full entrepreneurial talent to respond the challenges posed by COVID-19 and optimize global knowledge. Accordingly, the United Nations Economic Commission for Africa (ECA) and its partners have invited interested stakeholder to submit their innovations at the first Africa Innovation and Investment Forum 2020 that focused on COVID-19. This challenge will mainly focus on identifying business opportunities on the following five areas: Affordable rapid testing; Enhance medical devices and personal protection gear design and fabrication; Alternative tools for efficient and effective contact tracing and isolation; Development and production of potential drugs and vaccines in Africa. Who? This innovation challenge is open for all firms, individuals, research centers, innovation hubs, universities and institutes, government leaders and agencies and business leaders of all size and ages. When? The deadline for this application is 17:00 hrs East African Time on 05 June 2020 How? Send your submissions to: Mr. Gedion Workneh at: firstname.lastname@example.org and Mr. Asfaw Yitna, at email@example.com Benefits? The top 20 innovations selected in each of the 5 categories will be profiled on the ECA and partners’ websites at the Tech Market and Exhibition for Entrepreneurs and Investors; and the top 10 in each category will be given the opportunity to convince and get the support of governments, investors and potential partners and collaborators.